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KMID : 1039420190530060399
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Journal of Pathology and Translational Medicine
2019 Volume.53 No. 6 p.399 ~ p.402
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Concurrent Anti-glomerular Basement Membrane Nephritis and IgA Nephropathy
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Suh Kwang-Sun
Choi Song-Yi
Bae Go-Eun
Choi Dae-Eun
Yeo Min-Kyung
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Abstract
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Anti?glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of IgG along the GBM. In a limited number of cases, glomerular immune complexes have been identified in anti-GBM nephritis. A 38-year-old female presented azotemia, hematuria, and proteinuria without any pulmonary symptoms. A renal biopsy showed crescentic GN with linear IgG deposition along the GBM and mesangial IgA deposition. The patient was diagnosed as concurrent anti-GBM nephritis and IgA nephropathy. Therapies with pulse methylprednisolone and cyclophosphamide administration were effective. Concurrent cases of both anti-GBM nephritis and IgA nephropathy are rare among cases of anti-GBM diseases with deposition of immune complexes. This rare case of concurrent anti-GBM nephritis and IgA nephropathy with literature review is noteworthy.
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KEYWORD
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Anti-glomerular basement membrane disease, Immunoglobulin A, Crescentic glomerulonephritis
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